Cognitive Vitality - A Searchable Repository of Brain Health Information
The Alzheimer’s Hub of Hope has four sections: Heroes, Highlights, Headlines and Helpers/Caregivers. This post is aligned to the highlights section.
I’ve been writing this substack for over two years and use multiple search engines, ChatGPT, Grok and other tools to identify Alzheimer’s related news stories, research and resources. So I was surprised that the Cognitive Vitality website just recently was included in one of my searches since it doesn’t appear to be a new site.
This site is very robust and will provide you with multiple options to do your own homework. It may be worth your time to “click around the site” to see what it has to offer.
The site uses science-backed ratings for items that may improve you brain health. Its database of 395 items provides a detail analysis of:
9 food/drink items
14 Non-pharmacologic interventions (eg. breathing techniques, sauna)
80 supplements
109 drugs
170 drugs in development
13 risk factors
Here’s a link to the page that has links to all of their analysis in PDF format. I’ve also included these links at the bottom of this post.
Their analysis can be rather lengthy but I found them to be easy to read. It always includes a summary of the neurological benefit, evidence and safety of each item. I especially like that it includes the types of research (evidence) that was used to draw conclusions.
I’ve copied a section from the 24 page green tea analysis below to give you a feel for the content of their analysis.
There are many health benefits associated with green tea, including lower risk of dementia, cardiovascular disease, cancer, all-cause mortality, and others. It is generally safe in moderation.
Neuroprotective Benefit: Meta-analyses have found that green tea intake is associated with lower risks of dementia and cognitive decline. The association between green tea intake and better cognitive health may depend on ethnicity and other factors. Aging and related health concerns: Meta-analyses have reported that green tea intake is associated with lower risks of mortality, cardiovascular diseases, and many cancers. Green tea may also decrease body weight and improve lipid and metabolic profiles. Safety: Multiple meta-analyses have concluded that green tea consumption at moderate amounts is safe with mild side effects, but it is worth paying attention to the source of the tea leaves, as those grown in areas of excessive pollution can have lead contamination.
Types of evidence:
3 meta-analyses of observational studies
3 double-blind randomized controlled trials, 2 on cognitive function and 1 on acute effects of green tea extract
6 observational studies on cognitive function and/or dementia
1 clinical study of Alzheimer’s biomarkers
1 observational study on brain imaging metrics
1 review on tea and cognitive health in late life
Each of the 395 items is rated based on evidence (What is the strength of the research?), potential benefit (What is the likelihood that this will promote brain health?) and safety (Are there potential health risks to consider?).
Evidence ratings range from weak to strong. Benefit ratings range from low to high. Safety ratings range from low to high. All ranges go from 1 to 4.
The site includes a feature that allows the user to search the database based on several filters. For example, a person can search for items based on a combination of benefit, safety and evidence. The search function also provides the ability to search by item. For example, the results of searching for green tea links to this page which is a snapshot (summary) of the information in the 24 page PDF discussed above.
The search function is here.
Feel free to contribute $1.00 here to help support my work.
Links to Detailed Analysis
FOOD/DRINK
Acai Berries Download
Blueberries Download
Cocoa Download
Green Tea Download
Licorice Root Download
Olive Oil Download
Royal Jelly Download
Stevia Download
Wolffia globosa (Mankai) Download
NON-PHARMACOLOGIC INTERVENTIONS
Breathing Techniques Download
Cold-water immersion Download
CPAP for Obstructive Sleep Apnea Download
Focused Ultrasound Download
Inspiratory Muscle Strength Training Download
Meditation Download
Molecular Hydrogen Download
Oxygen Nanobubbles Download
Sauna Download
Time-Restricted Eating Download
Transcranial Direct Current Stimulation Download
Transcranial Magnetic Stimulation Download
Vagal Nerve Stimulation Download
Whole Body Cryotherapy Download
SUPPLEMENTS
2-Hydroxybenzylamine Download
7,8 Dihydroxyflavone Download
Aged Garlic Extract Download
Agmatine Download
Alpha-GPC Download
Alpha-ketoglutarate Download
Apigenin Download
Apoaequorin Download
Astaxanthin Download
Astragalus Download
Bacopa Monnieri Download
Benfotiamine Download
Berberine Download
Boswellia Download
Centella Asiatica Download
Centrophenoxine Download
Citicoline Download
Coffee Fruit Download
Creatine Download
Dihydromyricetin Download
Dinh Lang Download
D-serine Download
EGCG Download
Epithalamin & Epithalon Download
Ergothioneine Download
Fisetin Download
Fucoidan Download
Genistein Download
Ginkgo biloba Download
Glucosamine Download
Honokiol Download
Huperzine-A Download
Kamikihito Download
Krill Oil Download
Licorice Flavonoids Download
Lion's Mane Mushroom Download
L-Serine Download
L-Theanine Download
Lysophosphatidylcholine-Omega3 Download
Magnesium Download
Medium Chain Triglycerides Download
Melatonin Download
MitoQ Download
N-Acetylcysteine Download
NDGA Download
Nicotinamide Riboside Download
Omega-3 Fatty Acids Download
Oxaloacetate Download
Palmitoylethanolamide Download
Panax Ginseng Download
Pantethine Download
PB125 Download
Phosphatidylcholine & Lecithin Download
Phosphatidylserine Download
Plasmalogen Download
Policosanol Download
Polyamine Download
Postbiotics Download
Probiotics Download
Protandim Download
Psyllium Dowload
Pterostilbene Download
PTI-00703 Download
Resveratrol Download
S-Adenosylmethionine Download
S-equol Download
Sage Download
Selenium Download
Shankhpushpi Download
Silymarin Download
Soy Isoflavones Download
Sulforaphane Download
Souvenaid Download
Taurine Download
Tauroursodeoxycholic Acid Download
TA-65 Download
Tinospora Cordifolia Download
Trehalose Download
Triphala Download
Turkey Tail Mushrooms Download
Urolithin A Download
Ursolic Acid Download
Vinpocetine Download
Vitamin B6, B12, and Folate Download
Vitamin K2 Download
DRUGS
Acarbose Download
Allopregnanolone Download
Ambrisentan Download
AMX0035 Download
Angiotensin II Receptor Blockers Download
Anti-CD33 Download
Anti-IL6 and IL6R mAbs Download
Arimoclomol Download
Artesunate Download
Aspirin low-dose NSAID Download
Atomoxetine Download
Bacillius Calmette-Guerin Vaccine Download
Baricitinib Download
Bempedoic acid Download
Bisphosphonates Download
Bumetanide Download
Calcium Channel Blockers Download
Cannabidiol Download
Carvedilol Download
Cilostazol Download
Colchicine Low-dose Download
COMT Inhibitors Download
CSF-1R Inhibitors Download
Dabigatran Download
Daridorexant Download
Dexmedetomidine Download
DFMO Download
Dimethyl Fumarate Download
Donepezil Download
DPP-4 Inhibitors Download
Dual GIP/GLP-1 Receptor Agonists Download
Duloxetine Download
Edaravone Download
Efavirenz Download
EPA Download
Estetrol Download
Etifoxine Download
Fasudil Download
Fenofibrate Download
GLP-1 Receptor Agonists Download
GM-CSF Download
Guanfacine Download
Hachimijiogan Download
Hydroxychloroquine Download
Ibrutinib Download
Ibudilast Download
Igmesine Download
Ivermectin Download
Iron Chelators Download
IVIG Download
Lamivudine Download
Leflunomide & Teriflunomide Download
Lenalidomide Download
Levetiracetam Download
Lithium (Microdoses) Download
Lithium (Pharmaceutical) Download
Maraviroc Download
Memantine Download
Metformin Download
Methotrexate Download
Methylene Blue Download
Minocycline Download
Mirabegron Download
Mirodenafil Download
Modafinil Download
Montelukast Download
Nabilone Download
Naltrexone low-dose Download
Nicotine Download
Nilotinib Download
Nitazoxanide Download
Nooept Download
NSAID (Non-Aspirin) Download
Omaveloxolone Download
PDE5 Inhibitors Download
Pemafibrate Download
Pentoxifylline Download
Pioglitazone Download
Piracetam Download
Ramelteon Download
Rapamycin Download
Rasagiline Download
Retigabine Download
Rhein Download
Riluzole Download
Rivastigmine Download
Roflumilast Download
Rolipram Download
Rotigotine Download
Selegiline Download
Semaglutide Download
Semax Download
SGLT2 inhibitors Download
Shingles vaccine Download
Sodium Oligomannate (GV-971) Download
Sodium Phenylbutyrate Download
Sulfonylureas Download
Sulodexide Download
Suvorexant Download
Tacrolimus Download
Ticagrelor Download
Trametinib Download
Trazodone Download
Valacyclovir Download
Vorinostat Download
Vortioxetine Download
YangXue QingNao Download
Zileuton Download
DRUGS-IN-DEVELOPMENT
17α-Estradiol Download
2-Deoxy-D-Glucose Download
3K3A-Activated Protein C Download
A3R Agonists Download
AAV-hTERT Download
Aha1 Inhibitors Download
ALDH2 activators Download
ALZ-801 Download
Angiotensin 1-7 Download
ANGPTL3-Targeted Therapies Download
Anti-Atherosclerotic Nanoparticles Download
Anti-C1q Download
Anti-CD22 Download
Anti-IL-11 Download
Apabetalone Download
Apilimod Download
AR1001 Download
AZ-67 Download
Azeliragon Download
Bardaloxone Methyl Download
BIIB080 Download
BMS-984923 (ALX-001) Download
BPN14770 Download
Bryostatin Download
Buntanetap Download
Calmodulin-like skin protein Download
Cambinol Download
CaMKK2 Inhibitors Download
Carnosic acid Download
Caspase 2 Inhibitors Download
CETP Inhibitors Download
cGAS-STING Download
CK2 Inhibitors Download
CP2 Download
Crisdesalazine Download
Cutamesine Download
CSL112 Download
CT1812 (Elayta) Download
Cyclophilin Inhibitors Download
Dapansutrile Download
DHED Download
Dihexa Download
Duvax Download
DYRK1A Inhibitors Download
EC5026 Download
EGX358 Download
Elafibranor Download
ENT1 inhibitors Download
EP2 Antagonists Download
Exosomes Download
FGF21 Download
Fibronectin-1 Inhibitors Download
Fractalkine Modulators Download
FSH blocking antibody Download
Galectin-3 Inhibitors Download
GDF-11 Download
Gingipain Inhibitors Download
Ginsenoside Rg1 Download
Ginsenoside Rg3 Download
Gintonin Download
GPR39 Agonists Download
HBX Download
HDAC3 Inhibitors Download
HDAC11 Inhibitors Download
Homotaurine Download
Hsp90 inhibitors Download
Humanin and humanin analogs Download
Hydrogen sulfide Download
Hydroxypropyl-β-cyclodextrin Download
IBC-Ab002 Download
IGF1 Download
Immunoproteasome Inhibitors Download
Intranasal Glutathione Download
Intranasal Insulin Download
Intravenous Mesenchymal Stem Cells Download
Irisin Download
ISRIB Download
J147 Download
Klotho Download
KPT-350 Download
L3MBTL1 Inhibitors Download
Ligustilide Download
LINE1 Inhibition Download
LM11A-31 (C-31) Download
Lp(a) Download
Lonafarnib Download
Lrp1 Modulators Download
LRRK2 Inhibitors Download
LXR Agonists Download
MANF Download
MARK4 Inhibitors Download
MFGE8 Download
Mitochondrial Transplantation Download
MMF Prodrugs Download
MOTS-c Download
MP101/MP201 Download
MSUT2 Inhibitors Download
NE3107 (HE3286) Download
Nicotinamide Mononucleotide Download
NLRP3 Inhibitors Download
NNI-362 Download
Notum Inhibitors Download
NPTX2 Modulator Download
Nrf2 Activators Download
Nrf2 PPI Inhibitors Download
NSC001 Download
NX210c Download
O-GlcNAcase Inhibitors Download
OGG1 Agonists Download
Olamkicept Download
ORM-12741 Download
Osteocalcin Download
P021 Download
P110 Download
P2X7R Inhibitors Download
P2Y1R Inhibitors Download
P2Y6R Agonist Download
P38α MAPK Inhibitors Download
PAR4 Antagonists Download
Pepinemab Download
Piromelatine Download
Plasma exchange Download
Pomaglumetad Download
PPARδ Agonists Download
Pridopidine Download
Prosaposin Download
PRX-03140 Download
Psilocybin Download
Rabeximod Download
REST/NRSF Modulators Download
Retatrutide Download
RIPK1 Inhibitors Download
Roluperidone Download
RT001 Download
RTA-405 Download
S1P4R Antagonists Download
S3QELs Download
S6K1 Inhibitors Download
SAGE-718 Download
SBT-272 Download
Senolytics Download
SFX01 Download
SHIP1 Modulators Download
Simufilam (PTI-125) Download
SKQ1 Download
Small humanin-like peptides Download
SPG-302 Download
SS-31 Download
Sterubin Download
SXC-2023 Download
Syk Inhibitors Download
T regulatory cell Therapies Download
T3D-959 Download
Tanespimycin Download
THIK-1 Inhibitors Download
THN391 Download
Thyromimetics Download
TLR2 Inhibitors Download
TLR4 Inhibitors Download
Tramiprosate Download
Traneurocin (NA-831) Download
TRH Download
Trichostatin-A Download
Trodusquemine Download
Troriluzole Download
TRPM2 Inhibitors Download
TRPML1 Agonists Download
TQS-168 Download
URMC-099 Download
Vafidemstat (ORY-2001) Download
VBIT-4 Download
Verdiperstat Download
Volanesorsen Download
VX-765 Download
Xanamem Download
XPro1595 Download
RISK FACTORS
AGE Download
Air Pollution Download
Aluminum Download
Benzodiazepines Download
Diphenhydramine Download
Epigenetic Clocks Download
Erythritol and Xylitol Download
Mold and Mycotoxin Download
Oxymetazoline Download
Plastics Download
Polygenic Risk Score Download
Sleep (deficit/excess) Download
Textile Toxins Download
Fascinating information!